Endocrine Abstracts

Introduction: Daytime support from the diabetes-team reduces pressure on acute services however out-of-hours less support exists and diabetes related attendances to A&E are a potentially avoidable burden on resources. With the introduction of paediatric diabetes best-practice-tariff, recommendations included 24 h access to trained diabetes professionals for patients with known diabetes. In 2013 our three institutions created a consultant led out-of-hours paediatric diabete...

Late onset hypogonadism (LOH) is common in men with coronary artery disease (CAD) but its interaction with endothelial function and arterial structural changes is debatable.Aim: To investigate whether the LOH in men with CAD predicts endothelial dysfunction.Methods: Two hundred consecutive men with CAD and successful coronary stent implantation or coronary artery bypass grafting were included to the study group (mean age 59±10...

Introduction: In pregnant women there is a twofold increase in synthesis of calcitriol, i.e. the active metabolite of vitamin D. Literature data point to adverse effects of vitamin D deficiency during pregnancy both for pregnant woman and foetus. Polish data on the effects of vitamin D deficiency in this group are scarce.Aim of the study: The aim of this study was to evaluate the relationship between vitamin D3 concentrations in pregnant women on health ...

Aggravation of the symptoms of Alzheimer’s disease may also underlie the functioning of receptors associated with calcium and vitamin D. Therefore, it seems reasonable to study the correlation of polymorphisms of vitamin D receptor (VDR) and calcium receptor (CASR) with symptoms of AD. Alzheimer’s disease, vitamin D deficiency and osteoporosis often coexist in the patient. Research suggests that vitamin D deficiency is much more frequent in the patients with AD. Expr...

Introduction: Temozolomide (TMZ) can be administered as the last therapeutic option for aggressive pituitary tumors. Dopamine-agonist resistant prolactinomas are relatively frequent and remain a serious therapeutic problem. GH expressing atypical adenomas are rare and their positive response to TMZ is low. In a general opinion a lack of response to TMZ after three cycles predicts the treatment resistance.The aim of the study was presentation of two patie...

Introduction: The empty sella syndrome (ESS) is defined as the penetration of the subarachnoid space into intrasellar region. In ESS pituitary hormonal function is usually normal, but several, mostly subtle, hormonal abnormalities have been also reported. The coexistence of Cushing’s disease and primary empty sella is very rare.Objective: The presentation of an exceptional case of a patient with Cushing’s disease associated with primary empty s...

Introduction: Crooke’s cells are normal corticotrophs with cytoplasmic accumulation of cytokeratin filaments in response to glucocorticoids excess. Crooke’s cell corticotropinomas are the unique cause of Cushing’s disease. Nearly all of them are invasive macroadenomas, generally aggressive, refractory to conventional therapy, with high recurrence rate.Aim of the study was to present a case study of a patient with Cushing’s disease cau...

Introduction: Aggressive corticotropinomas are more invasive than other pituitary tumors. Recent reports have documented the efficacy of temozolomide alone or in combination with an anti-angiogenic agent –bevacizumab in invasive pituitary adenomas treatment.Objective: Presentation a case of 56-year-old woman initially diagnosed as Cushing’s disease and the analysis of treatment procedures with special concentration on temozolomide and bevacizum...

Background: Elastography is an ultrasound technique that allows to predict risk of malignancy of examined lesion by assessing their stiffness. Its effectiveness in thyroid nodules is equivocal which may result from insufficient standardization.Aim: Analysis of factors affecting the repeatability and reproducibility of elastographic measurements of thyroid nodules.Methods: 124 nodules in 118 patients were analyzed. Elastographic mea...

Background: Elastography is a procedure that widen diagnostic ultrasonography (US) but its significance in thyroid diagnostics has not been settled.Aim: Comparison of usefulness of elastography and conventional malignancy risk features (MRF) in the diagnostics of thyroid nodules, analysis of elastographic characteristics of follicular lesions of undetermined significance (FLUS).Methods: Analysis included 38 benign lesions (BL), 15 ...